Organisme : Instituts de recherche en santé du Canada
	Projets financés à l'Université Laval
		A 2x2 factorial randomized controlled trial to elucidate how ultra-processed foods modulate cardiometabolic risk
		Addressing stigmatization of Indigenous patients: Co-developing structural and educational strategies through a nuanced understanding of cultural risk in the Quebec healthcare system
		Adrenergic control of liver metabolism in obesity and diabetes
		Age-related patterns in the experience of chemotherapy-induced peripheral neuropathy
		A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies
		Air pollution, climate and COPD: acute and long-term impacts in Canadian populations
		Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders
		Améliorer la prédiction du risque cardiovasculaire en considérant les stresseurs psychosociaux au travail
		Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies
		Anatomically relevant brachytherapy implants by a 3D printing and radiosenstizing approach
		A non-restrictive approach to facilitate appetite control and long-term body weight loss in individuals with obesity: can we do better?
		Anti-Thrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (ATTACC-CAP)
		A Phase 2 study of Trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathwa
		Apnea, sex and FMO: Are flavin-containing monooxygenases the new anti-ox that prevent metabolic disorders under intermittent hypoxia?
		A Pre-Clinical Research for Treatment of Prematurity and BronchoPulmonary Dysplasia through Intracrinology
		A Randomized Trial of Partial Breast Irradiation
		A Randomized Trial of Regional Radiotherapy in Luminal A Breast Cancer
		A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease
		Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication
		A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living with HIV
		ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension
		A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease
		Autoantibodies and antibody-producing cells in neurological autoimmune diseases: from biology to therapeutic targeting
		Biological sex, sex chromosomes and heart failure
		Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia
		Blocking the Effects of Serotonin to Prevent Ischemic Mitral Regurgitation: a Randomized Trial
		Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
		BRAINapt: TBI International Adaptive Platform Trial
		Brain magnetic stimulation to reduce levodopa-induced dyskinesias in Parkinson’s disease
		Causes and consequences of anti-PEG antibodies
		Cellular characterization of a novel putative immune biomarker of MS progression
		Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays.
		Characterizing and monitoring the healthfulness of the food supply: a fundamental step towards creating healthier food environments
		COMPLETE-2: A prospective, randomized, multi-centre trial of physiology-guided versus angiography-guided complete revascularization to treat multivessel
		Complex genetics of hypertrophic cardiomyopathy: Towards an integration of polygenic risk in clinical care
		Computational neuroscience modelling of cognitively healthy aging and Alzheimer's disease
		Control of metabolic inflammaging by traffic of B lymphocytes in adipose tissues
		Deafnesses: Reconfiguring expertise and reconsidering sensory experiences with/out the cochlear implant
		Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
		Deciphering the role of PTPN6/SHP-1 and its mutant PTPN6/SHP-1Ala455Thr in the development of pulmonary emphysema
		Deciphering the role of the Yin Yang1 (YY1) transcription factor to understand pleuropulmonary blastoma
		Defining the global transcriptional response to perturbations
		Defining the role of DEPTOR in the regulation of brown adipose tissue development/function and evaluation of its impact on systemic metabolism
		Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models
		De la perte de contrôle alimentaire au trouble d'accès hyperphagique: trajectoires évolutives et facteurs de risque.
		Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders
		Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models
		Dérivation et validation d'un outil de stratification du risque applicable en préhospitalier et visant à identifier les personnes âgées nécessitant des soins urgents ou une hospitalisation à la suite d’une chute
		Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia
		Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease
		Dissecting the cortico-striatal and tegmental pathways’ contribution to stress response
		Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures
		Dysregulation of TET2 and DNMT3A promotes pulmonary arterial hypertension (PAH) through inflammation : A new mechanism of PAH
		Early markers of cardiovascular disease and lifestyle habits in youth with type 1 diabetes followed to young adulthood
		Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE)
		Elimination of senescent endothelial cells to prevent vascular dementia in aging atheroscierotic mice
		Elucidating patient and healthcare practitioner decision-making about chemotherapy-induced peripheral neuropathy-related
		Elucidating the role of the IL-1 system in the pathogenesis of CNS autoimmunity
		Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury
		Elucidation of bromodomain functions within SWI/SNF complexes
		Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy
		Engineering a vascularized macroencapsulation device for diabetes cellular therapy
		Engineering bioactive dressings from mesenchymal cells to enhance healing of irradiated skin wounds
		Enhancing speech perception in noise in healthy older adults and in older adults with cognitive impairment using non-invasive brain stimulation
		Epigenome wide study for the investigation of DNA methylation as therapeutic target and novel biomarker of pulmonary arterial hypertension
		Evaluating and facilitating the implementation of stepped and measurement-based mental health care in Family Medicine Groups
		Evaluating the ongoing impact of COVID-19 on youth substance use and mental health trajectories over time: renewal of the COMPASS prospective cohort.
		Exploring the biology of the hepatokine TSK in health and disease.
		Exploring the Interplay between Metabolic and Epigenetic Signalling Pathways to Regulate Neointima Hyperplasia
		Exploring the role of phosphoinositides in the trafficking of proteins to the apical complex in the malaria parasite Plasmodium falciparum
		Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population
		Fatty acid metabolism in carriers of apolipoprotein E. epsilon 4 allele: determining the blood-to-brain link
		Favoriser l'engagement des femmes ayant eu un cancer du sein dans les décisions concernant l'hormonothérapie adjuvante prolongée
		FGF-21 in Alzheimer's disease
		Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited
		Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
		Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
		Functional dissection of the serotoninergic system in normal and pathological conditions
		Function and neuroprotective potential of new target genes against Parkinson's disease
		Genetic dissection of propriospinal interneuronal pathways and their reticulospinal inputs pertaining to locomotor control and recovery after spinal cord injury
		Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers
		Global signals in dendrites of GABAergic inhibitory interneurons : mechanisms and function
		Host iNOS dictates gut dysbiosis, bacterial translocation and tissue insulin resistance in murine and human obesity
		How does insulin interact with the blood-brain barrier? Therapeutic implications for diabetes and Alzheimer’s disease
		HPV vaccination effectiveness in a Canadian setting, 12 years after implementation: are we on the road to eliminate cervical
		Human herpesvirus 6 and chromosomal integration
		Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice
		Identification of innate immune pathways as targets for immunomodulatory therapy in herpes simplex virus encephalitis
		Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy
		Identifying nutrition and lifestyle mediators of genetic susceptibility to obesity: towards a precision lifestyle medicine approach to obesity prevention
		Imaging Substudy of the BEST Trial: Balloon-Expandable versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis
		Impact of an Angiotensin Receptor Blocker in Aortic Stenosis - a Randomized Controlled Trial
		Impact of dietary stearidonic acid-rich oil on rheumatoid arthritis
		Improving mental health pratices recovering from traumatic injuries: Identifying prioritiez based on knowledge to practice gaps and interested parties needs and preferences
		Improving the quality of Canadian pediatric injury care: identifying priorities based on evidence, practice variations and stakeholder needs and preferences
		Influence of Dopamine on Motor Learning and Stroke Recovery
		Inhibitory control of hippocampal inhibitory circuits: cell types, neuromodulation and function
		Integrating Multi-Omics, Multi-Modal Neuroimaging and Artificial intelligence for Biologically-defined Staging and Statification in the Alzheimer's Disease spectrum
		Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract
		Investigate the mechanisms regulating the fibrotic reaction mediated by perivascular cells in cerebrovascular disorders
		Investigating mechanisms of altered lipid metabolism in amyotrophic lateral sclerosis (ALS)
		Is a stepped model of care cost-effective compared to usual care for chronic musculoskeletal disorders? A randomized controlled trial
		Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia
		L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1
		La modulation des ganglions de la base par les afférences neurochimiques du tronc cérébral : implication dans la physiopathologie des troubles du mouvement
		La neuroplasticité du noyau subthalamique et de ses afférences en provenance du tronc cérébral: Implications dans la physiopathologie de la maladie de Parkinson
		Le bon soin au bon patient, au bon moment mais avec quelle modalité? Préférences des médecins omnipraticiens et des patients (fiche enfant - Gestion éthique)
		Le bon soin au bon patient, au bon moment mais avec quelle modalité? Préférences des médecins omnipraticiens et des patients (Fiche Parent pour Transferts inter et institutionnels)
		LEFT HF: LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
		Les conduites paternelles et la transmission intergénérationnelle des problèmes de santé mentale : une étude de cohorte père-mère-enfant débutant à la période prénatale
		Linking neonatal stress and anomalies of immune development in rats: novel insights into the origin of sex-based differences in viral infection severity
		Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery
		Managing pain in collaboration in the intensive care unit (MPIC-ICU): Impact on clinical practices and patient outcomes
		Maternal sleep-disordered breathing during pregnancy and long-term health outcomes in children: the 3D pregnancy and birth cohort
		Mechanisms and function of wrappER contacts with mitochondria and peroxisomes in health and disease
		Mechanisms of action of sex-specific endocrine treatments in complementary models of Parkinson's disease
		Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1
		Mechanisms regulating contribution of pericytes to brain repair after stroke
		Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure for Older Patients with Cryptogenic Stroke and Patent Foramen Ovale: A Randomized Trial Research Proposal
		Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases
		Microglia as a viral reservoir for HIV-1 in the human brain and its role in neuroinflammation
		Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies
		Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability
		Modulation of cortical excitability with transcranial direct current stimulation: toward prevention of trauma-induced neocortical epileptogenesis
		Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse
		Molecular characterization of newly identified silicon transporters in animals
		Multi-Centre Cluster-Randomized Implementation of Canadian Syncope Pathway for Emergency Department Syncope Management
		Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair
		Neurodevelopmental vs. Neurodegenerative: A study of neurodevelopmental consequences of FTD genetic mutations in at-risk youth
		Neurovascular adaptations driving stress-induced depression vs resilience
		Nouvelles options thérapeutiques pour les patients atteints de psoriasis
		Nutrient sensing mechanisms underlying the metabolic effects of dietary proteins in obesity and type 2 diabetes
		Obstructive Sleep Apnea and Long-Term Health Consequences
		Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues
		Optical Nanoscopy of cytoskeletal and synaptic remodeling in neurons
		Optimizing HPV vaccination programs in Low- and Middle-Income Countries (LMIC) and High-Income Countries (HIC) to reduce inequalities and reach global elimination of cervical cancer: An integrated knowledge translation dynamic-modeling
		Optimizing patient adherence to stroke rehabilitation treatment: a telerehabilitation trial
		Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne
		Orthologous CRISPR-Cas9 systems for genome editing: discovery, characterization and development for novel biotechnological applications
		Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model
		PARP inhibition in PAH: A Phase 1 clinical trial
		Periacetabular Osteotomy with or without arthroscopic management in patients with hip dysplasia: A multicenter randomized controlled trial
		Personal Social Networks, Built Environment and Cardiometabolic Risk Factors: a Prospective Investigation with Young Adults
		Physiotherapy care in Emergency Departments for Patients with Musculoskeletal Disorders: A Pragmatic Cluster Randomized Controlled Trial and Cost Analysis
		Pilot study of a community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast
		Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis
		Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality
		Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS)
		Prebiotics to modify the gut microbiome and enhance immune checkpoint blockers
		Pre-clinical pharmacokinetic and efficacy assays with an efficient 17beta-hydroxysteroid dehydrogenase type 7 inhibitor for breast cancer therapy
		Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease
		Prévenir l’hypertension, le diabète de type 2 et les maladies cardiovasculaires en ciblant les stresseurs psychosociaux au travail, les longues heures de travail et les mauvaises habitudes de vie : Des fractions
		Preventing pathological protein spread in Huntington's disease: relevance to pathology and treatment
		Prévention du cancer du col de l’utérus en Côte d’Ivoire, Afrique de l’Ouest : Évaluation de l’efficacité du vaccin quadrivalent
		Promoting healthy eating in early pregnancy in women at risk of gestational diabetes mellitus : does it improve glucose homeostasis ?
		Promoting healthy eating in early pregnancy in women at risk of gestational diabetes mellitus: does it improve glucose homeostasis?
		Prospective Evaluation of Breast-Conserving Surgery Alone in Low Risk Ductal Carcinoma in Situ Defined by a Molecular Expression Assay Combined with Clinico-Pathological Features
		Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer
		Real World Clinical and Economic Burden of Severe Burn Injuries
		Reducing low-value practices in acute trauma care: a pragmatic cluster randomized controlled trial
		Régénération de la peau humaine : Une peau reconstruite par génie tissulaire pigmentée produite plus rapidement pour traiter les patients grands brûlés
		Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model
		Réparation des lésions des nerfs périphériques par génie tissulaire
		Rewiring the brain efficiently with cell transplantation in a pre-clinical model of Parkinson's disease
		Risk stratification and personalized therapy in lupus pregnancies
		Role and regulation of EPB41L5 in cancer-promoting cellular processes
		Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt
		Role of inflammation in recovery after spinal cord injury
		Role of megakaryocytes in Systemic Lupus Erythematosus
		Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease
		Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias
		Selective neuroimaging for head-injured emergency patients who take anticoagulant medication.
		Sex and Gender in Digital Health
		Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea.
		Sex, hormones, and fertility: elucidating the molecular mechanism of action of transcription factor GATA4 in reproductive function
		Sex-specific role of pericytes in stress-induced neurovascular changes underlying depression pathogenesis and treatment response
		Signal integration and action potential coding in hippocampal microcircuits
		Situating Suicide Risk: An inquiry into the production of the lives and afterlives of neurobiological vulnerability
		Sleep and Circadian Misalignment and their Relation to Cardiometabolic Health during Adolescence
		Soulager la douleur chronique chez les aînés à l'aide de la stimulation transcrânienne par courant direct
		Strategies for the management of Atrial Fibrillation in patiEnts receiving HemoDialysis (SAFE-HD)
		Stress and loss of ovarian function: novel insights into the origins and treatment of respiratory control disorders in females
		Stress Hydrocortisone in Pediatric Septic Shock (The SHIPSS trial)
		Surveillance of Complex Renal Cysts: The SOCRATIC study
		Targeting Hypusine signaling: an opportunity to counter pulmonary vascular remodelling in pulmonary arterial hypertension
		Targeting Mitosis and Senescence to Reverse Pulmonary Hypertension: A Promising Therapeutic Strategy
		Targeting mRNA translation to effectively treat uveal melanoma
		Targeting sex steroids to improve the response to bladder cancer immunotherapy
		Testosterone on airway hyperresponsiveness in asthma
		The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel
		The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation
		The Canadian CABG or PCI in Patients with Ischemic Cardiomyopathy (STICH 3.0) Trial
		The Canadian Severe Acute Respiratory Infection, Prospective, Perpetual Observational Study: Informing Clinical Care and the Public Health Response
		The impact of Monte Carlo dose calculations on prostate and breast low-dose rate brachytherapy dose-outcome relationships and radiobiological modeling
		The impact of the in utero environment on the developing human brain: Longitudinal investigations on epigenetic mechanisms in monozygotic twins from birth to adolescence
		The implication of PlGF in cutaneous fibrosis
		The interplay of sex hormones and chromosomes dictates pathogenicity in progressive CNS autoimmunity
		The molecular and functional impact of stress in the medial prefrontal cortex
		Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques
		Therapeutic Plasma Exchange in Septic Shock (PLEXSIS): A Pilot Study
		The Ribosomal RNA Genes in Growth, Pluripotency, Senescence and Cancer
		The right care, for the right patient, at the right time, by the right provider: A value-based comparison of the management of ambulatory respiratory diseases in walk-in clinics, primary care physician practices and emergency departments
		The role of chronic stress reactivity in the persistence of insomnia over time
		The test-negative design for the estimation of COVID-19 vaccine effectiveness: design evaluation and development of statistical methods in the evolving context
		The UGT to GUS equilibrium as novel target for the treatment of cholestatic autoimmune liver diseases
		Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes
		Toward a paradigm shift in the promotion of healthy eating: Systematic development and feasibility testing of an intervention
		Towards a comprehensive model of Spindle Assembly Checkpoint silencing
		Towards Personalized Dosimetry-Based Radioligand Therapy of Prostate Cancer as a New Standard of Practice
		Training Intervention and Program of Support (TIPS) for fostering the adoption of family-centred telehealth interventions in pediatric rehabilitation: A pan-Canadian implementation-effectiveness study
		Trajectories of Externalizing Behaviour Problems and New Parents’ Distress and Harsh Parenting: A Genetically-Informed, Prospective Longitudinal Study
		Transitioning patients with advanced chronic kidney disease to home or facility dialysis: understanding the experience and quality of life for patients and their caregivers (TRANSIT-CARE)
		Understanding Delirium Pathophysiology using Urine Metabolomics from Older People with Hip Fractures
		Understanding mitochondrial metabolism to identify prostate cancer metabolic vulnerabilities
		Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing.
		Un nouveau vecteur de médicaments ophtalmiques à base de nanoparticules d'or
		Unraveling the functional domains of a novel pluripotency-associated lncRNA
		Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus
		Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach
		Unravelling the role of ARHGEF3 during skin development and hair follicle regeneration
		Unravelling the role of primary cilia in prostate cancer initiation and progression
		Usage d'analgésiques en conditions réelles de pratique chez les personnes vivant avec de la douleur chronique : Une approche novatrice de modélisation de la polypharmacie sous forme de trajectoires de risque
		Usage du cannabis et ses effets sur le déroulement et l'issue de la grossesse, la santé et le développement de l'enfant d'âge préscolaire
		Validation et raffinement prospectif multicentrique des Quebec Brain Injury Categories pour les patients ayant subi un