Fiche détaillée de la technologie

Titre de la technologie / Technology Title
    High-titer retrovirus packaging cell lines that grow in suspension and synthetic medium
Description / Description
    The present invention relates to non-replicative recombinant retrovirus packaging cells able to grow in suspension in a serum-free medium. In particular, the present invention relates to a human embryonic 293SF-based cell line stably expressing gag and pol gene products from the murine Moloney leukemia virus (MLV) and the feline RD114 env gene. This particular combination allows the production of high titer of non-replicative retrovirus pseudotyped and prevents the recombination of plasmids. The recombinant retroviruses produced from these cells are safer and easier to produce for clinical use in gene therapy
Fiche descriptive / Fact sheet
    Inventeur / Inventor Collaborateur(s) / Collaborator(s)
    • Karim Ghani
    Contact / Contact Champs(s) d'intérêt(s) / Industry segment(s) Brevet(s) / Patent(s) Numéro de la technologie / File Number : 00687